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KMID : 1189420040170030018
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2004 Volume.17 No. 3 p.18 ~ p.25
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Effects of SaMulTangGamibang(SMTG) on the Inflammatory Reactions
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Yun Chan-Ho
Roh Seok-Sun
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Abstract
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This study was carried out to investigate the effects SMTG on the skin inflammatory reactions. Among the herbal ingredients of SMTG, ethanol extracts of Paeoniae obovata Radix and Acanthopanacis Cortex showed potent radical scavenging activity, more than 90% at a concnentration of 0.01%, tested by DPPH(1,l-diphenyl-2-picryl-hyrazyl) method. And ethanol extract of Saururi Herba Seu Rhizoma inhibited the lipopolysaccharide-induced release of nitric oxide(NO), 94% at 50 ㎍／㎖, by the macrophage RAW 246.7 cells. In addition, the ethanol extract of Acanthopanacis Cortex showed antibacterial activities on Staphylococcus aureus that was reported to cause impetigo and atopic disease. Taken together, I expect that SMTG may be used as a drug for treatment on skin inflammation.
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KEYWORD
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inflammation , radical scavenging activity , nitric oxide
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